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Hypothalamic Kiss1 and Gnrh1 mRNA of rhGH rats were significantly higher than those of controls on PND 24, indicating early activation of hypothalamic kisspeptin-GnRH neurons by rhGH

There were also no significant differences between groups on frailty status score, physical function, nutritional status, and the biochemical tests using MannWhitney test

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For researchers building comprehensive GH-axis studies, understanding how each peptide positions within a broader peptide stack including GHRP companions, tissue-repair compounds, and IGF-1 analogs is essential for rigorous experimental design